"Audience of One" is a song by the American punk rock band Rise Against, written by the band's frontman Tim McIlrath. It is the second single from their 2008 album Appeal to Reason. Hitting number four on the Billboard Alternative Songs chart, "Audience of One" is Rise Against's third-highest charting single, behind the previous single from Appeal to Reason, "Re-Education (Through Labor)", which peaked at number three and the third single "Savior".

In mid-October 2008, the L.A. radio station KROQ began playing "Audience of One." Its video was announced to be shot with director Brett Simon on December 9. On January 15, the video for "Audience of One" premiered on MySpace. The single was released on CD and 7" vinyl on March 3, 2009 in the UK. The song is also a downloadable song in Guitar Hero World Tour.

"Audience Of One" is featured with a customized Rise Against Theme in Tap Tap Revenge 2 for the iPhone and iPod Touch. It is featured again in the aforementioned game's sequel, Tap Tap Revenge 3, in a double pack that also includes Ready to Fall.