Stark

Thomas Stark is a man with spinal muscular atrophy (SMA), using an electric wheelchair. While he and his assistance dog were crossing the street he faints (syncope) and is almost hit by an SUV.

House sets his team of ten fellowship candidates to compete in a race to find the diagnosis first. To do this he splits them into two teams: men and women, but Amber Volakis (Anne Dudek) elects to defect to the men's team. When House suggests this is because she thinks the female candidates are inept, she says it's because House has never had more than one woman on his staff so if he's going to fire an entire gender it will be the women's team. Because of her previous behavior trying to get on the team, including getting others fired, House and the other fellowship candidates begin calling her "Cut-throat Bitch." Amber continues to do whatever she feels it takes to get the job, initially starting by attempting to schmooze Dr. Cameron into giving her advice.

Initially, Thirteen (Olivia Wilde) treats him for strongyloides with ivermectin but with no favorable changes. The doctors eventually decide that they have cured him, and House holds a "tribal council" and fires some of the doctors, including Amber. Amber then turns to Dr. Chase, and attempts to appeal to his grudge against House for firing him in order to get him to help perform some blood tests that she no longer has privileges to do. However, Stark develops a pulmonary aspiration then renal failure and pneumonia and eventually dies from asphyxiation because of the pneumonia. House, Thirteen, and Jody discover that his assistance dog has also died. Based on Dr. House's knowledge of the dog's genes (as a Collie, it has a defect in the MDR1 gene), a search of the room reveals that Stark did not take the ivermectin, but the dog did. Autopsy of Stark reveals that he indeed had Strongyloides, confirming Thirteen's diagnosis.

House confronts Thirteen, who failed to watch Stark take the ivermectin, with a lecture on her screw-up. He does not fire her because he's positive she will not make a similar mistake again. He does, however, fire the other three members of Thirteen's team: the twins and Jody. This leaves seven candidates remaining.

House

In the clinic, House encounters a patient wearing a cervical collar who, immediately upon House's entry, sticks a knife into an outlet and tries to electrocute himself. Later he reveals that the best 97 seconds of his life were when he was "technically dead" after being hit by a drunk driver and before paramedics revived him. When House tells him that his oxygen-starved brain shut down, releasing endorphins and serotonins that caused his visions, the patient insists that the experience was unlike any hallucinogenic drug he experienced and he believes that there is more than mortal life. This is in direct opposition to House's belief that there is no afterlife of any kind.

When the teams postulate that Stark has cancer, Wilson is brought in for a consult. Stark's dismissal of an additional few months to live leads House to deride his philosophical beliefs. Wilson confronts House, saying that he doesn't know any better than anyone whether there is an afterlife. House later uses the knife he took from the clinic patient to electrocute himself (after paging Amber seconds before to come resuscitate him). The experiment sends him into a temporary coma, forcing Wilson to take over the differential and potential candidates. At first, the potential fellows, unfamiliar with the depths of House's eccentricity, think that House has attempted suicide. When House finally wakes up, he finds Wilson waiting for him. Wilson demands to know why House did it, and House reveals he wanted to see for himself what would happen while he was close to dead. Wilson reminds him he's had two near death experiences already (references to "Three Stories" and "No Reason"). He tells House that "just looking at you hurts. I'm gonna order up some extra pain meds." House replies, "I love you", and his tone is unexpectedly heartfelt.

Although House does not reveal what he saw to Wilson (only asking for the clinic patient, who Wilson informs him has died), he tells Stark's body in the morgue, "I'm sorry to say, I told you so," indicating that he saw no afterlife.

Foreman

Foreman is head of a diagnostic department at New York Mercy and leads a team of at least four (including himself), much like House was at Princeton-Plainsboro. He is faced with a patient who has similar symptoms as in "House Training" where he chose radiation to treat cancer but was a simple Staph infection. Foreman believes this patient has anaplastic large cell lymphoma but his boss tells him to stick to the rules/protocol and administer a cephalosporin (a type of antibiotic).

Late at night, Foreman decides to treat with radiation. Tests reveal that this treatment saved her life because she, indeed, had cancer. Since Foreman didn't follow the rules and — according to the un-Cuddyish Dean of Medicine — "confused saving her life with doing the right thing", she fired him.