The episode starts with a man heading out the door to work. As he progresses down the stairs, the stairwell begins to sway, and he vomits. Brent Mason (Kip Pardue) finds his wife Kara (Hillary Tuck) in the bathtub having a seizure, and their newborn infant, Mikey, drowning. Chase, who is working in both the Neonatal Intensive Care Unit and the Diagnostics department, takes the case and asks House for help. Foreman returns after his near-death experience in the last two episodes. He is suffering from mild memory loss but is in a very good mood. Throughout the episode, he does not argue with House's ideas, which annoys House. Mikey seems fine until his lung collapses. House says it is caused by bacterial problems, and Chase starts Mikey on ECMO. When the treatment appears to be working, he returns to Kara, who is attempting to smother Mikey and says she is hearing voices. The baby eventually dies from the smothering attempt. Chase feels guilty that he did not do enough, even though there was nothing to prevent death from happening eventually due to the organ damage. House starts to think that both Kara and Mikey had the same problem, so he directs Chase to autopsy Mikey. After praying for Mikey, Chase realizes that the baby has flattened intestinal villi. House and Wilson think that Kara and Mikey have Coeliac disease, explaining her bleeding due to Vitamin K deficiency and Pellagra due to Vitamin B3 deficiency, and leaves her susceptible to cancer. Neither of them are successful in convincing her to receive treatment, including her husband. Kara wishes to die because she believes she was fully responsible for Mikey's death, even though she was powerless to do anything else than what the "voices" said that she should do.

Meanwhile House and Wilson try to find out why Cuddy asked Wilson to have dinner with her. House buys her trash from a janitor to investigate. He finds a box of red clover, which among other things is used by cancer patients. House believes the date is a consult.

Wilson later runs a PCR test on Cuddy's spoon. The results show that she is negative for all cancer markers, but House notices that her estrogen is unusually high. He realizes that the red clover was a herbal booster for fertility, and that Cuddy was considering Wilson as a sperm donor. House keeps this a secret, and tells Wilson that Cuddy had some skin lesions.